{"id":248,"date":"2025-02-27T11:12:58","date_gmt":"2025-02-27T03:12:58","guid":{"rendered":"https:\/\/www.biowing.com.cn\/?post_type=product&p=248"},"modified":"2025-08-08T17:09:47","modified_gmt":"2025-08-08T09:09:47","slug":"cgfwsnpfx","status":"publish","type":"product","link":"https:\/\/www.biowing.com.cn\/index.php\/product\/cgfwsnpfx\/","title":{"rendered":"SNP\u5206\u578b"},"content":{"rendered":"

SNP<\/strong>\u4ecb\u7ecd<\/strong><\/p>\n

SNP\u5168\u79f0Single Nucleotide Polymorphism\uff0c\u5373\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\uff0c\u662f\u6307\u5728\u57fa\u56e0\u7ec4\u4e0a\u5355\u4e2a\u6838\u82f7\u9178\u7684\u53d8\u5f02\uff0c\u5305\u62ec\u8f6c\u6362\uff0c\u98a0\u6362\uff0c\u63d2\u5165\u548c\u7f3a\u5931\uff0c\u5f62\u6210\u7684\u9057\u4f20\u6807\u8bb0\uff0c\u5176\u6570\u91cf\u5f88\u591a\uff0c\u591a\u6001\u6027\u4e30\u5bcc\uff0c\u6709\u4e9bSNP\u4f4d\u70b9\u76f4\u63a5\u5f71\u54cd\u57fa\u56e0\u529f\u80fd\uff0c\u4ece\u800c\u5bfc\u81f4\u751f\u7269\u6027\u72b6\u6539\u53d8\u3002<\/p>\n

SNP\u662f\u7814\u7a76\u4eba\u7c7b\u5bb6\u65cf\u548c\u52a8\u690d\u7269\u54c1\u7cfb\u9057\u4f20\u53d8\u5f02\u7684\u91cd\u8981\u4f9d\u636e\uff0c\u56e0\u6b64\u88ab\u666e\u904d\u7528\u4e8e\u7fa4\u4f53\u9057\u4f20\u5b66\u7814\u7a76\u548c\u75be\u75c5\u76f8\u5173\u57fa\u56e0\u7684\u7814\u7a76\u3002<\/p>\n

\u4e0a\u6d77\u7ffc\u548c\u751f\u7269SNP\u5206\u578b\u670d\u52a1\uff1a<\/p>\n

\u6839\u636e\u5177\u4f53\u5b9e\u9a8c\u89c4\u6a21\uff0c\u63d0\u4f9b\u4e24\u79cd\u68c0\u6d4b\u5e73\u53f0\uff0c\u5206\u522b\u4e3a\uff1a\u9002\u5408\u4e2d\u4f4e\u901a\u91cf\u68c0\u6d4b\u7684PCR-LDR\u00a0SNP\u5206\u578b\u670d\u52a1\u548c\u9002\u5408\u9ad8\u901a\u91cf\u7684\u57fa\u4e8e\u4e8c\u4ee3\u6d4b\u5e8f\u7684Hi-SNP\u5206\u578b\u670d\u52a1\u3002<\/p>\n

PCR-LDR SNP<\/strong>\u5206\u578b\u670d\u52a1<\/strong><\/p>\n

PCR-LDR\u6280\u672f\u662fPCR\u6280\u672f\u548cLDR(Ligase Detection Reaction,\u8fde\u63a5\u9176\u68c0\u6d4b\u53cd\u5e94)\u60f3\u7ed3\u5408\u7684\u68c0\u6d4b\u6280\u672f\u3002<\/p>\n

LDR\u662f\u5229\u7528\u9ad8\u6e29\u8fde\u63a5\u9176\u5b9e\u73b0\u5bf9\u57fa\u56e0\u591a\u6001\u6027\u4f4d\u70b9\u7684\u8bc6\u522b\u3002\u9ad8\u6e29\u8fde\u63a5\u9176\u4e00\u65e6\u68c0\u6d4b\u5230DNA\u4e0e\u4e92\u8865\u7684\u4e24\u6761\u5be1\u805a\u6838\u82f7\u9178\u63a5\u5934\u5bf9\u5e94\u5904\u5b58\u5728\u7740\u57fa\u56e0\u70b9\u7a81\u53d8\u7c7b\u578b\u7684\u78b1\u57fa\u9519\u914d\uff0c\u5219\u8fde\u63a5\u53cd\u5e94\u5c31\u4e0d\u80fd\u8fdb\u884c\uff0c\u53cd\u4e4b\u5219\u53ef\u4ee5\u8fdb\u884c\u8fde\u63a5\u53cd\u5e94\u3002<\/p>\n

\u6280\u672f\u539f\u7406\uff1a<\/strong><\/p>\n

\"22222222222222.png\"<\/strong><\/p>\n

\u6280\u672f\u8def\u7ebf\uff1a<\/strong><\/p>\n

\"\u56fe\u72476.png\"<\/p>\n

\u8be5\u68c0\u6d4b\u6280\u672f\u9002\u5408\u5404\u7c7b\u4e2d\u4f4e\u901a\u91cf\u7684SNP\u68c0\u6d4b\u89c4\u6a21\uff0c\u5982QTL\u5b9a\u4f4d\u7814\u7a76\u8def\u7ebf\u3001\u5019\u9009\u57fa\u56e0\u6216\u4f4d\u70b9\u5173\u8054\u5206\u6790\u3001\u5206\u5b50\u80b2\u79cd\u7b49\u3002<\/p>\n

Hi-SNP<\/strong>\u5206\u578b\u670d\u52a1<\/strong><\/p>\n

Hi-SNP\u7ed3\u5408\u591a\u91cdPCR\u6280\u672f\u548c\u9ad8\u901a\u91cf\u6d4b\u5e8f\u6280\u672f\uff0c\u5bf9\u9700\u8981\u68c0\u6d4b\u7684\u4f4d\u70b9\u8bbe\u8ba1\u7279\u5f02\u6027\u5f15\u7269\uff0c\u5728\u5355\u7ba1\u5185\u8fdb\u884c\u591a\u91cdPCR\u6269\u589e\uff0c\u4e0d\u540c\u7684\u6837\u672c\u4ee5\u4e0d\u540c\u7684Barcode\u5f15\u7269\u533a\u5206\u3002\u6df7\u5408\u6837\u672c\u540e\uff0c\u5728Ion\u00a0Proton\/illumina\u00a0\u4e3b\u6d41\u6d4b\u5e8f\u5e73\u53f0\u4e0a\uff0c\u5bf9\u6269\u589e\u5b50\u8fdb\u884c\u9ad8\u901a\u91cf\u6d4b\u5e8f\u3002\u6d4b\u5e8f\u7ed3\u679c\u4f7f\u7528\u751f\u7269\u4fe1\u606f\u5b66\u65b9\u6cd5\uff0c\u533a\u5206\u4e0d\u540c\u7684\u6837\u672c\uff0c*\u7ec8\u83b7\u5f97\u6bcf\u4e2a\u4f4d\u70b9\u7684SNP\u4fe1\u606f\u3002\u9ad8\u901a\u91cf\u6d4b\u5e8f\u80fd\u4e00\u6b21\u5bf9\u51e0\u767e\u4e07\u6761DNA\u5206\u5b50\u8fdb\u884c\u5e8f\u5217\u6d4b\u5b9a\uff0c\u76f8\u6bd4\u5176\u4ed6\u7684SNP\u68c0\u6d4b\u6280\u672f\uff0c\u57fa\u4e8e\u9ad8\u901a\u91cf\u6d4b\u5e8f\u7684SNP\u5206\u578b\u5177\u6709\u66f4\u51c6\u786e\u3001\u66f4\u7075\u654f\u7684\u7279\u70b9\u3002<\/p>\n

\u6280\u672f\u539f\u7406\uff1a<\/strong><\/p>\n

\"2.png\"<\/strong><\/p>\n

\u6280\u672f\u8def\u7ebf\uff1a<\/strong><\/p>\n

\"\u56fe\u72478.png\"<\/p>\n

\u672c\u65b9\u6cd5\u9002\u7528\u4e8e\u5f88\u591a\u7684\u9057\u4f20\u5b66\u7814\u7a76\u9886\u57df\uff0c\u4f8b\u5982\u75be\u75c5\u57fa\u56e0\u7ec4\u7814\u7a76\u3001**\u57fa\u56e0\u7ec4\u7814\u7a76\u3001\u75be\u75c5\u4e0e\u57fa\u56e0\u7684\u5173\u8054\u7814\u7a76\u3001\u4e34\u5e8a\u5206\u5b50\u8bca\u65ad\u7814\u7a76\u7b49\uff0c\u5728\u690d\u7269\u57fa\u56e0\u7ec4\u7814\u7a76\u4e2d\uff0c\u53ef\u7528\u4e8eQTL\u5b9a\u4f4d\u53ca\u5206\u5b50\u80b2\u79cd\uff0c\u975e\u5e38\u9002\u5408\u5927\u89c4\u6a21\u6837\u54c1\u7684SNP\u5206\u6790\u3002<\/p>\n

\u5ba2\u6237\u90e8\u5206\u8bba\u6587\u53d1\u8868<\/strong><\/p>\n

1.Li J, Huang S, Dai H R, et al. A promoter polymorphism rs2075824 within IMPA2 gene affecting the transcription activity: possible relationship with schizophrenia.[J]. Journal of Cellular & Molecular Medicine, 2016.<\/p>\n

2.Chen K, Zhou Y X, Li K, et al. A novel three-round multiplex PCR for SNP genotyping with next generation sequencing[J]. Analytical and Bioanalytical Chemistry, 2016, 408(16):1-7.<\/p>\n

3.Chen Z J, Zhao H, He L, et al. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.[J]. Nature Genetics, 2011, 43(1):55-59.<\/p>\n

4.Shi Y, Li Z, Xu Q, et al. Common variants on 8p12 and 1q24.2 confer risk of schizophrenia.[J]. Nature Genetics, 2011, 43(12):1224-7.<\/p>\n

\n","protected":false},"excerpt":{"rendered":"

SNP\u5168\u79f0Single Nucleotide Polymorphism\uff0c\u5373\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\uff0c\u662f\u6307\u5728\u57fa\u56e0\u7ec4\u4e0a\u5355\u4e2a\u6838\u82f7\u9178\u7684\u53d8\u5f02\uff0c\u5305\u62ec\u8f6c\u6362\uff0c\u98a0\u6362\uff0c\u63d2\u5165\u548c\u7f3a\u5931\uff0c\u5f62\u6210\u7684\u9057\u4f20\u6807\u8bb0\uff0c\u5176\u6570\u91cf\u5f88\u591a\uff0c\u591a\u6001\u6027\u4e30\u5bcc\uff0c\u6709\u4e9bSNP\u4f4d\u70b9\u76f4\u63a5\u5f71\u54cd\u57fa\u56e0\u529f\u80fd\uff0c\u4ece\u800c\u5bfc\u81f4\u751f\u7269\u6027\u72b6\u6539\u53d8\u3002
\nSNP\u662f\u7814\u7a76\u4eba\u7c7b\u5bb6\u65cf\u548c\u52a8\u690d\u7269\u54c1\u7cfb\u9057\u4f20\u53d8\u5f02\u7684\u91cd\u8981\u4f9d\u636e\uff0c\u56e0\u6b64\u88ab\u666e\u904d\u7528\u4e8e\u7fa4\u4f53\u9057\u4f20\u5b66\u7814\u7a76\u548c\u75be\u75c5\u76f8\u5173\u57fa\u56e0\u7684\u7814\u7a76\u3002<\/p>\n","protected":false},"featured_media":249,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[20,27],"product_tag":[],"class_list":{"0":"post-248","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-jsfw","7":"product_cat-cgfw","9":"first","10":"instock","11":"shipping-taxable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/www.biowing.com.cn\/index.php\/wp-json\/wp\/v2\/product\/248","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biowing.com.cn\/index.php\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/www.biowing.com.cn\/index.php\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biowing.com.cn\/index.php\/wp-json\/wp\/v2\/comments?post=248"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.biowing.com.cn\/index.php\/wp-json\/wp\/v2\/media\/249"}],"wp:attachment":[{"href":"https:\/\/www.biowing.com.cn\/index.php\/wp-json\/wp\/v2\/media?parent=248"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/www.biowing.com.cn\/index.php\/wp-json\/wp\/v2\/product_brand?post=248"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/www.biowing.com.cn\/index.php\/wp-json\/wp\/v2\/product_cat?post=248"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/www.biowing.com.cn\/index.php\/wp-json\/wp\/v2\/product_tag?post=248"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}