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APOE<\/strong>\u57fa\u56e0<\/strong>\u68c0\u6d4b||\u00a0\u9884\u9632\u8001\u5e74\u75f4\u5446<\/strong><\/h1>\n

ApoE<\/strong>\u00a0<\/em><\/strong>\u57fa\u56e0\u591a\u6001\u6027\u4e0e\u963f\u5c14\u5179\u6d77\u9ed8\u6c0f\u75c7<\/strong><\/h1>\n

ApoE\u57fa\u56e0\uff08\u8f7d\u8102\u86cb\u767dE\uff09\u4f4d\u4e8e\u7b2c19\u53f7\u67d3\u8272\u4f53\u4e0a\uff0c\u5177\u5907\u663e\u8457\u9057\u4f20\u591a\u6001\u6027\uff0cApoE\u57fa\u56e0\u5e38\u89c1\u76842\u4e2a\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\u4e3a(rs429358\u548crs7412)\u3002\u5176\u591a\u6001\u6027\u4e0e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08\u8001\u5e74\u75f4\u5446\uff09\u5bc6\u5207\u76f8\u5173\u3002\u8fdb\u884cApoE\u57fa\u56e0\u591a\u6001\u6027\u68c0\u6d4b\uff0c\u8ddf\u636e\u5927\u91cf\u79d1\u5b66\u7814\u7a76\u7ed3\u679c\uff0c\u53ef\u4ee5\u5bf9\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08\u8001\u5e74\u75f4\u5446\uff09\u8fdb\u884c\u63d0\u524d\u9884\u9632\u3002<\/p>\n

<\/p>\n

ApoE<\/strong>\u00a0<\/em><\/strong>\u57fa\u56e0<\/strong>\u7ed3\u6784<\/strong><\/h1>\n

ApoE \u57fa\u56e0\u4f4d\u4e8e19\u53f7\u67d3\u8272\u4f53\uff0c\u5168\u957f3.7Kb\uff0c\u542b4\u4e2a\u5916\u663e\u5b50\u3002ApoE\u57fa\u56e0\u67092\u4e2aSNP\u4f4d\u70b9rs429358\u548crs7412\uff0c3\u79cd\u7b49\u4f4d\u57fa\u56e0\u03b52\u3001\u03b53\u3001\u03b54\uff0c\u5176\u4e2d\u4ee5\u03b53\u7a81\u53d8\u6700\u4e3a\u5e38\u89c1\uff0c\u76f8\u4e92\u7ec4\u5408\u5f62\u62106\u79cd\u4e3b\u8981\u57fa\u56e0\u578b\uff1a\u03b52\/\u03b52\u3001\u03b52\/\u03b53\u3001\u03b52\/\u03b54\u3001\u03b53\/\u03b53\u3001\u03b53\/\u03b54\u3001\u03b54\/\u03b54\u3002<\/p>\n

<\/p>\n

ApoE<\/strong>\u00a0<\/em><\/strong>\u57fa\u56e0\u4e0e\u963f\u5c14\u5179\u6d77\u9ed8\u6c0f\u75c7<\/strong>\u98ce\u9669<\/strong><\/h1>\n

\u867d\u7136\u4e09\u79cdApoE\u86cb\u767d\u5728\u4e00\u7ea7\u7ed3\u6784\u4e0a\u53ea\u6709\u4e00\u4e2a\u6c28\u57fa\u6b8b\u57fa\u7684\u5dee\u522b\uff0c\u4f46\u5176\u7a7a\u95f4\u6784\u8c61\u5374\u5b58\u5728\u5f88\u5927\u5dee\u522b\uff0c\u9020\u6210ApoE\u4e0d\u540c\u7684\u8868\u578b\u5728\u75be\u75c5\u4e2d\u6709\u7740\u622a\u7136\u4e0d\u540c\u7684\u5f71\u54cd\u3002<\/p>\n

<\/p>\n

 <\/p>\n\n\n\n\n\n\n\n\n\n
\u57fa\u56e0<\/strong><\/td>\n\u7b49\u4f4d\u57fa\u56e0<\/strong><\/td>\nrs429358<\/strong><\/td>\nrs7412<\/strong><\/td>\n\u57fa\u56e0\u578b<\/strong><\/td>\n\u89e3\u8bfb<\/strong><\/td>\n<\/tr>\n
 <\/p>\n

 <\/p>\n

ApoE<\/strong><\/td>\n

\u03b52\/\u03b52<\/td>\nTT<\/td>\nTT<\/td>\nE2\u578b\uff08\u957f\u5bff\u578b\u57fa\u56e0\uff09<\/td>\n\u5360\u4eba\u7c7b\u76847%\uff0c\u8fd9\u7c7b\u57fa\u56e0\u578b\u7684\u4e2a\u4f53\u4e0d\u6613\u60a3\u8001\u5e74\u75f4\u5446\u75c7\u3001<\/td>\n<\/tr>\n
\u03b52\/\u03b53<\/td>\nTT<\/td>\nTC<\/td>\n<\/tr>\n
\u03b53\/\u03b53<\/td>\nTT<\/td>\nCC<\/td>\nE3\u578b\uff08\u5e38\u89c1\u578b\u57fa\u56e0\uff09<\/td>\n\u5360\u4eba\u7c7b\u768478%\uff0c\u5bf9\u673a\u4f53\u6b63\u5e38\u751f\u7406\u529f\u80fd\u53d1\u6325\u8d77\u5173\u952e\u4f5c\u7528\u3002<\/td>\n<\/tr>\n
\u03b52\/\u03b54<\/td>\nTC<\/td>\nTC<\/td>\n<\/tr>\n
\u03953\/\u03b54<\/td>\nTC<\/td>\nCC<\/td>\nE4\u578b\uff08\u98ce\u9669\u578b\u57fa\u56e0\uff09<\/td>\n\u5360\u4eba\u7c7b\u768415%\uff0c\u6613\u60a3\u8001\u5e74\u75f4\u5446\u75c7\u3002<\/td>\n<\/tr>\n
\u03954\/\u03b54<\/td>\nCC<\/td>\nCC<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08Alzheimer\u2019s disease\uff0cAD\uff09\u662f\u5e38\u89c1\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u4e3b\u8981\u75c5\u7406\u7279\u5f81\u5305\u62ec\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\uff08\u03b2- amyloid\uff0cA\u03b2\uff09\u7ec4\u6210\u7684\u8001\u5e74\u6591\u548c\u8fc7\u5ea6\u78f7\u9178\u5316\u86cb\u767d\u7ec4\u6210\u7684\u795e\u7ecf\u5143\u7ea4\u7ef4\u7f20\u7ed3\u3002\u5176\u53d1\u75c5\u4e0eApoE\u57fa\u56e0\u591a\u6001\u6027\u6709\u5173\uff0c\u5927\u7ea660%\uff5e80%\u7684AD\u60a3\u8005\u6709\u81f3\u5c11\u4e00\u4e2aE4\u7b49\u4f4d\u57fa\u56e0\uff0c\u56fd\u5185\u5916\u7814\u7a76\u663e\u793a\uff0c\u643a\u5e261\u4e2aE4\u7b49\u4f4d\u57fa\u56e0\u4f7f\u98ce\u9669\u589e\u52a02\uff5e4\u500d\uff0c\u800c\u62e5\u67092\u4e2aE4\u7b49\u4f4d\u57fa\u56e0\u7684\u4eba\u7684\u98ce\u9669\u63d0\u9ad88\uff5e12\u500d\u3002\u4e0e\u975eE4\u643a\u5e26\u8005\u76f8\u6bd4\uff0cE4\u643a\u5e26\u8005\u53d1\u75c5\u5e74\u9f84\u5e73\u5747\u964d\u4f4e\u7ea612\u5c81\u3002\u56e0\u6b64APOE4\u643a\u5e26\u8005\uff1aAD\u53d1\u75c5\u7387\u9ad8\uff0c\u53d1\u75c5\u5e74\u9f84\u65e9\u3002<\/p>\n

 <\/p>\n

ApoE\u7684\u57fa\u56e0\u578b\u7ec8\u8eab\u5f71\u54cd\u4eba\u4f53\u7684\u5065\u5eb7\u548c\u751f\u6d3b\u65b9\u5f0f\uff0c\u5b83\u6307\u5bfc\u4e2a\u4eba\u7684\u996e\u98df\u4e60\u60ef\uff0c\u5e2e\u52a9\u4fdd\u6301\u826f\u597d\u8eab\u4f53\u72b6\u51b5\uff0c\u9884\u9632\u7cfb\u5217\u91cd\u5927\u75be\u75c5\u53d1\u751f\uff0c\u4e00\u65e6\u60a3\u75c5\uff0c\u8fd8\u51b3\u5b9a\u7740\u4e0e\u4f17\u4e0d\u540c\u7684\u4e2a\u4f53\u5316\u6cbb\u7597\u3002<\/p>\n

\u68c0\u6d4b\u539f\u7406<\/strong><\/h1>\n

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 <\/p>\n

 <\/p>\n

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APOE\u57fa\u56e0\u68c0\u6d4b||\u00a0\u9884\u9632\u8001\u5e74\u75f4\u5446
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